Wednesday, November 27, 2019
McDonaldââ¬â¢s restaurants Essay Example
McDonaldââ¬â¢s restaurants Essay In reviewing Subwayââ¬â¢s recent economic performance, the restaurant franchise chain is confident in their day to day operation. Subway is still expanding and one day will they will outnumber the amount of McDonaldââ¬â¢s restaurants. Subwayââ¬â¢s purchasing power is high due to the 33,000 location within 90 different countries. (Subway) Cost Analysis The price for a sandwich from Subway is fairly stable across all 33,000 locations. A person can order the same sandwich form any of these restaurants. So no matter where in the world a person is they can still order their meatball sandwich. Normally a person can order a sandwich, chips, and drink for less than ten dollars. Demand Analysis The demand for fast food has risen throughout the years. McDonaldââ¬â¢s is the largest fast-food chain followed by Subway. Subway offers fast-food services with healthier alternatives. As people are short on time to get food, they are also demanding a healthier lifestyle. Subway has answered the call, The Subwayà ® chain is doing this through a variety of tactics, including the 8 subs with 6 grams of fat or less and other low-fat choices; a family marketing strategy; and an emphasis on unique qualities that make the chain stand out from other fast-food chains. (Subway) Competitor Analysis Subway faces several competitors, anywhere from small mom and pop sandwich shops to other large restaurant chains. Subwayââ¬â¢s top three competitors are McDonaldââ¬â¢s, Quiznos, and Yum! Brand Inc. Yum! We will write a custom essay sample on McDonaldââ¬â¢s restaurants specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on McDonaldââ¬â¢s restaurants specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on McDonaldââ¬â¢s restaurants specifically for you FOR ONLY $16.38 $13.9/page Hire Writer is the largest fast food operator in the world in terms of number of locations, with more than 37,000 outlets in about 110 countries. The companyââ¬â¢s flagships chains include KFC, Pizza Hut, Taco Bell, Long John Silverââ¬â¢s, AW Root Beer, with 80% of their restaurants licensed to franchisees. (Yahoo) Action Plan Subway will keep doing what they are doing in order to become the largest sandwich restaurant in the world. With a growth of about 2,000 stores a year they will one day outnumber the number of McDonaldââ¬â¢s locations. SUBWAYà ® restaurants Franchise fee: $12,000 Start-up cost: $69,300 to $191,000 Basic royalty: 8% Advertising royalty: 3. 5% BLIMPIE* Franchise fee: $18,000 Start-up cost: $99,321 to $338,200 Basic royalty: 6% Advertising royalty: 4% BURGER KING* Franchise fee: $50,000 Start-up cost: $240,000 to $2. 5 million Basic royalty: 4. 5% Advertising fund: 4% COUSINââ¬â¢S SUBS* KFC McDonaldââ¬â¢s Franchise fee: $15,000 Franchise fee: $25,000 Franchise fee $45,000 Start-up cost: $200,000 average Start-Up Cost: $250,000 Start-Up Cost $432,000 to $715,150 Basic royalty: 6% Basic royalty: 7. 90% Basic royalty: 12. 5% Advertising royalty: 2% Service fee: 4. 90% Module 15 ââ¬â DETERMINING ORGANIZATIONAL FINANCIAL RESULTS Revenue Sources In 2008, Subway made $926. 2 million dollars in sales. That is a 1. 9% sales growth for the sandwich shop chain. In 2008 they employed 700 employees working at their headquarters. They are expecting a 9. 7% growth within their work force. Due to the fact most stores are a franchise the profit margin varies from store to store because they are independently owned. Therefore each store must pay their employees from each stores profit instead of coming from a corporate office. (Doctorââ¬â¢s Associates Inc) Operating Costs Due to the fact most Subway restaurants are privately held by different individuals the operating cost varies from location to location. Generally speaking each store must pay 8% of their sales to royalty costs. The cost in which it takes to run the stores will include land or rent payments, the cost of raw materials in order to make the food, electricity, and any other services in which the store might need to be successful. Start-Up Costs In order to open up a new Subway restaurant a business will need $78,600 to $238,300 for their total investment. The initial franchise fee is $15,000 with royalties of 8%. The owner of the new store has to agree to the terms of agreement for 20 years. (Franchise Mall) Profitability According to Doctorââ¬â¢s Associates Inc they cannot promise any projected profit or return on investment for new Subway franchises. Doctorââ¬â¢s Associates Inc release this statement because there is no magic formula in order to make a Subway franchise be success. Although In 2009, Doctorââ¬â¢s Associates made $926. 2 million dollars in sales from their 8% royalties. That is a 1. 9% sales growth for the sandwich shop chain. It is hard to get an actual number on how profitably each franchise is due to the fact they are all independently owned. Location and the customer base are all factors on how successful each location is. ( Subway) Action Plan With around $300,000 a person can open their own Subway restaurant store. 8% of the stores revenue will have to pay back for royalties. To be very successful and make a nice living a person will need to own and operate several stores. There is money to be made and a market to be taken. (Subway) MODULE 16- MEASURING INTERNATIONAL BUSINESS SUCCESS Financial Gains The profitable Subway franchise will undoubtedly profit from our operations in Brazil. Merging Subwayââ¬â¢s success with Brazilââ¬â¢s culture will be Subwayââ¬â¢s primary interest. Economic Benefits Subwayââ¬â¢s focus will be equal opportunity for males and females alikeââ¬âthe majority of Brazilââ¬â¢s workforce is made up of men who earn higher salaries. Social Benefits Expanding Subwayââ¬â¢s franchise to Brazil will be the stepping stone to expanding in neighboring countries. Because Subway will be adapting Brazilââ¬â¢s culture into our products and services, we will be preserving and enhancing Brazilian culture. Social Costs Subway was founded in the United States, a country with values much different than Brazil. In fact, many American values are considered to be offensive in the Brazilian culture. We must closely monitor our companyââ¬â¢s practices prior to expansion. References countrystudies.us/brazil/82.htm.
Saturday, November 23, 2019
States With No Income Tax Should You Move to One
States With No Income Tax Should You Move to One SAT / ACT Prep Online Guides and Tips While everyone in the US pays a federal income tax, not everyone pays a state income tax. There are seven states in the US with no income tax whatsoever, plus two more that donââ¬â¢t tax wages. While people who live in these states donââ¬â¢t pay income tax, they may pay higher taxes in other ways, like when they go shopping or stop at the gas station. This guide will explore whether or not people in income tax-free states save money overall, along with the pros and cons of moving to one of these states. First, letââ¬â¢s look at the nine states with few or no taxes on income. What Are the States With No Income Tax? There are seven states with no income taxes whatsoever. They are the following: Alaska Florida Nevada South Dakota Texas Washington Wyoming Two other states, New Hampshire and Tennessee, donââ¬â¢t have an income tax on wages, but they do tax interest and dividend income. If youââ¬â¢re making money from investments, for instance, then that profit would be taxed in New Hampshire or Tennessee. The remaining 41 states do level a tax on income. Some have a flat-rate income tax, while others have different brackets based on how much money you make. These states gain revenue from income taxes, and that money goes into various services and programs. In states that donââ¬â¢t collect income tax, where does the revenue come from? There are nine states in the U.S. with no or few state income taxes. Lokal Profil/Wikimedia Where Do States With No Income Tax Get Revenue? States still need revenue, and they get that money from a variety of sources. Commonly, states without income tax have higher sales, gas, and property taxes. They may also provide fewer, more expensive, or lower quality public services. For instance, in-state tuition at the public universities in New Hampshire is higher than that of most other states. Letââ¬â¢s look on a state-by-state basis to see how these no-income-tax states collect revenue. Alaska: petroleum revenue. Because of its oil, Alaska is an exception among income tax-free states. Rather than raising other taxes, Alaska actually distributes a dividend check to residents. Last year, each residentââ¬â¢s share was $2,075. Florida: above average sales taxes and property taxes. Nevada: gambling-related fees and taxes, as well as sales taxes. South Dakota: personal taxes, property taxes, cigarette excises, bank franchises, and ore taxes. Texas: oil and gas royalties, as well as a high sales tax. Washington: some of the highest sales and gasoline taxes in the United States. Wyoming: coal mining and property taxes. Like Alaska, Wyoming also gets revenue from its natural resources. New Hampshire: property tax. Tennessee: highest sales tax in the US. Given these alternative forms of revenue collection, does living in a state without income tax mean you keep more of your paycheck? Alaskan residents actually get money back each year from the Alaska Permanent Fund. Living in Alaska can be expensive, though, as itââ¬â¢s a pretty remote place. Does Living in an Income Tax-Free State Mean You Keep More of Your Money? The short answer to this question is, not necessarily. As you can see above, many states without income tax charge higher taxes on day-to-day expenses. They may also provide fewer public services or more expensive higher education. Depending on your spending habits and lifestyle, the amount of money youââ¬â¢re paying toward other taxes could be higher than the amount you would pay toward taxes overall in a state that had an income tax. How much you benefit from an income tax-free policy also largely depends on your income level. Typically, people with a higher income benefit from the lack of income tax, while people with lower incomes end up paying a larger percentage of their salary to other kinds of taxes. According to the Institute on Taxation and Economic Policy in Washington, for example, the poorest 20% of state residents pay 16.9% of their annual income in sales and gas taxes, while the wealthiest 1% pay just 2.4% of their income. Your income level, therefore, becomes an important factor if youââ¬â¢re deciding whether or not to move to a state with no income tax. What else should you consider as you figure out where to live in the United States? Should you move to sunny Florida, where palm trees are a-plenty but state income tax is nowhere to be found? Who Should Move to an Income Tax-Free State? As you read above, income tax-free states tend to have higher sales, gas, and property taxes and a reduced budget for public programs, like education. If any of the following are true for you, then you might benefit from living in one of these states. If the opposite is true, then you probably shouldnââ¬â¢t move to one. You Have a High Income Higher-income people tend to benefit the most from living in an income tax-free state. Besides keeping a larger proportion of your wages, higher income people may also have less need for public services. For instance, higher-income people may not rely on public education, instead sending their kids to private schools. You Donââ¬â¢t Own Much Property If you donââ¬â¢t own a lot of property, then you wonââ¬â¢t get hit too hard with the often high property taxes in income tax-free states. If you do own a lot of property, then living in one of the nine states discussed above probably wouldnââ¬â¢t work in your favor. If you own a lot of land or houses, then you may end up getting hit with high property taxes. You Donââ¬â¢t Spend a Lot Besides having higher property taxes, most of these nine states impose high sales taxes. If you have a high consumption lifestyle, then youââ¬â¢ll be putting a higher than average percentage of your income toward sales taxes. If you donââ¬â¢t spend a lot, then you may save money in one of these states overall. You Donââ¬â¢t Rely on Public Services States without income taxes may offer reduced or lower quality public services, like transportation, health care, or public education. If you donââ¬â¢t have kids or are sending your kids to private school, then this might not affect you. Washington, by the way, is an exception with its strong public school system, but it has some of the highest sales and gas taxes in the country. If you drive a lot in Washington, then you might end up paying a lot in gas tax and highway and bridge tolls. If youââ¬â¢re sending kids to public school, be careful about the quality of the education system in an income tax-free state. You Hold Conservative or Libertarian Views People have different opinions about state income tax, and their support of or opposition to it tends to coincide with their social and political views. People with progressive or liberal views tend to support government funding of public services, like education, health insurance, and transportation, and they tend to be in favor of income taxes, as well. Those with more conservative or libertarian views want to minimize the governmentââ¬â¢s role in shaping society and consequently, tend to be opposed to income taxes. They may oppose any kind of income redistribution and prefer that all people pay the same on other taxes, like sales taxes. Progressives, however, point out that sales taxes affect people at different incomes disproportionately, with lower income populations becoming the most burdened. People also disagree about whether income taxes help or hinder job and population growth. Those who oppose income tax say that doing away with it boosts jobs and helps the state retain young people. According to a 2013 study, though, Texas was the only non-income tax state where job growth didnââ¬â¢t lag behind population growth. If you find yourself agreeing with the typically conservative or libertarian point of view opposed to state income tax, then you may well enjoy living one of the nine states listed above. Are you a progressive, conservative, or libertarian? Whether or not you support state income taxes tends to align with your social and political views. Youââ¬â¢ve Done Your Research Beyond figuring out whether living in an income tax free state would be financially beneficial for you, you should also base your decision on a number of other factors, like the stateââ¬â¢s culture and weather and what your moving process would be like. Are you ready to move to Nevadaââ¬â¢s desert climate and live close to the temptation of gambling? Does the libertarian bent of many Texans appeal to you? Are you comfortable living in a remote place like Alaska where the sun shines all summer and hides all winter? Any move calls for a good deal of research and planning. If your main motivation is doing away with income tax, then remember that there are other factors to consider, like state services and how the governmentââ¬â¢s alternative methods of revenue collection affect you as an individual or family. If you do decide to pack up and move to the desert of Nevada or a ranch out in the Lone Star state, what steps do you need to take? Besides bringing lots of water, what steps would you need to take to move to a state with no income tax, like Nevada? How to Move to a State With No Income Tax In order to move and start enjoying an income tax-free life, youââ¬â¢ll typically need to establish both state residency and domicile. Residency and domicile laws vary by state. Typically, youââ¬â¢ll need to spend a certain amount of time in the state, as well as change some records to reflect your new address. One common law states that you canââ¬â¢t spend more than 183 days in any single state beside your new state of residency. Thatââ¬â¢s not to say you have to spend the remaining 182 days in your new state of residency. For instance, letââ¬â¢s say youââ¬â¢re moving to Texas. You spend 100 days in Texas, 100 days in Massachusetts, and 165 days in California. Since you didnââ¬â¢t spend a collective 183 days in a single state other than Texas, you can still call Texas your state of residency. However, if you had spent 100 days in Texas and the remaining 265 days in California, then you canââ¬â¢t call Texas your state of residency. Again, your time in one other state canââ¬â¢t exceed 183 days. While establishing residency is pretty straightforward, establishing domicile is a bit more vague. Generally, domicile means that your community connections need to be stronger in your new state than your old state. These connections include things like your voter registration, driverââ¬â¢s license, and bank accounts. You also have to indicate that the new state will be your permanent home. Since residency and domicile requirements vary by state, youââ¬â¢ll have to check the exact specifications for Texas, Wyoming, and the rest of the states with no income taxes. Besides rooting out the exact residency laws, make sure to remember these key points about states with no income taxes and how to move to one. One perk of living in a state with no income tax- you can totally skip that page on your tax returns. States With No Income Tax: Final Thoughts While eliminating an income tax might sound like it saves you money, the policy is a little trickier than it sounds. States still need money, so getting rid of an income tax typically means that they impose higher taxes in other areas. The only exception is states that generate revenue from natural resources, like Alaska with its petroleum. Whether living in a state with no income tax will save you money varies by individual. Typically, people who have a high income will benefit, as well as those who donââ¬â¢t rely on public education, drive very much, own a lot of property, or spend much money overall. Youââ¬â¢ll have to take a look at your income, lifestyle, and spending habits to determine whether moving would be financially beneficial for you. Because of the U.S.ââ¬â¢s unique mix of state and federal laws, you should always look into tax laws when youââ¬â¢re considering moving. If youââ¬â¢re envisioning relocating to another part of the country, then consider the new stateââ¬â¢s tax laws and how theyââ¬â¢ll affect your personal finances.
Thursday, November 21, 2019
Factors Impacting Ethical Behavior in a Chinese State owned Essay
Factors Impacting Ethical Behavior in a Chinese State owned steelCompany - Essay Example To a larger extent, it can be observed that the work environment significantly impacts on the ethical behaviour of the employees in the organization. Chinaââ¬â¢s business ethics is based on Confucianism and this also shapes the work environment in different organizations (Fu & Deshpande, 232). The ethical climate that exists in the organization greatly shapes the ethical behaviour of the Chinese employees. This environment shapes the values, perceptions as well as the beliefs that shape the behaviour of people. Likewise, Chinese employees are likely to learn from others within the organization and they will behave in a way that reflects the organizationââ¬â¢s values and norms. In a country with uncertainty avoidance like China, it has been observed that the climate in the Chinese steel organization is shaped by such rule and this ultimately shapes ethical behaviour of the employee (Fu & Deshpande, 235). Thus, the prescribed values that obtain in the work environment significant ly shape the ethical behaviour of the Chinese employees. The other significant factor that shapes ethical behaviour of the Chinese is related to employee evaluation of self and other co-workers. As noted by Fu & Deshpande (235), employees in the steel industry share collectivist behaviour and this also shapes their ethical behaviour. The employees are greatly influenced by the behaviour of their co-workers since they would not want to be found on the wrong side of the law. In most cases, if the employees see other people in the organization behaving wrongly then they are not punished, they are likely to follow suit. Likewise, if the co-workers see others being rewarded for good behaviour, they will also behave in a positive way. Therefore, to a larger extent, it can be noted that the way employees evaluate themselves and their co-workers significantly impacts on their ethical behaviour in the
Wednesday, November 20, 2019
Park plaza county hall london Essay Example | Topics and Well Written Essays - 3000 words
Park plaza county hall london - Essay Example This has resulted to a rise in the level of customer satisfaction. Different scholars of the world have described the state of the UK hospitality market as ââ¬Ëfast-changingââ¬â¢. This means that the particular hotels in this industry have to race to keep up with the pace. The fast changing nature of this industry has further been attributed to the technological advancements of the world. The different hotels have to therefore direct more of their resources and time to the emerging technology-based techniques and communication platforms such as social media to remain appealing to the evolving demographics of the world. Newer market segments continues to emerge in the hospitality industry in UK what has perpetrated the changes experienced in the market where most customers today are going for fast, better and more personalized services. London continues to be viewed as the ââ¬Ëgrowth engineââ¬â¢ of the hotel sector in UK following the high number of hotel businesses located in the city. Hotel business in London is appealing following the fact that London it is a major tourist destination. Throughout the year, London experiences influx of visitors from all parts of the world. This has resulted in a boom in the hotel business in the city. The main objective of this market report is to evaluate the market operations of Park Plaza County Hall London hotel through use of specific market analysis tools; PESTEL analysis and market mix-7Ps and how the market operations impact the hotel business of Park Plaza County Hall London hotel. This market report was commissioned to specifically examine the role and contributions of marketing to the success of a business by looking into the operations of Park Plaza County Hall London hotel in the UK hospitality industry. It further offers specific recommendations that can adequately be integrated by the business to enhance its performance within this industry. According to Baines and Page (2010, p.
Sunday, November 17, 2019
Piagets stages of development Essay Example for Free
Piagets stages of development Essay Sensory Motor Stage Piagetââ¬â¢s first stage of development is the sensory motor stage. This stage occurs between the birth of the child and the age of two. During this stage, understanding comes from touching, sucking, chewing, and manipulating objects. About nine months after birth, the child develops what is called ââ¬Ëobject permanenceââ¬â¢. Object permanence is the awareness that objects and people continue to exist even if they are out of sight. The infants have the ability to build up mental pictures of objects around them, from the knowledge that they have developed on what can be done with the object. Through manipulation, babies accumulate information on themselves and the world that lead to the slight understanding of how one thing can cause or affect another, and begins to develop simple ideas about time and space. An example of this would be that a baby can realize that if they cry when they are hungry, the mother will attend to them (Fleck, 1975, p. 3). Preoperational Stage Piagetââ¬â¢s second stage of development was the preoperational stage. The preoperational stage of development occurs between the ages of two to seven years. During this stage, childrenââ¬â¢s though processes are developing. There is a development of language and use of symbols. Children still use egocentric thought, meaning that they view the world entirely from his or her own perspective. ââ¬ËAnimismââ¬â¢ is also a characteristic of the preoperational stage. This is when a person has the belief that everything that exists has some kind of consciousness. An example of this would be that a child would believe the sink isnââ¬â¢t turning on because it is sick or that the water will be hot because itââ¬â¢s angry. A child at this stage of development appears to view his social relationships and the physical reality egocentrically. This means that they view the world with a marked tendency to evaluate interaction with others in terms of its contribution to their own experience of satisfaction. So moral realism is an aspect of this stage because children think that their thoughts on the difference between right and wrong are shared by everyone else around them. (Appel, 1977, p. 4). Concrete Operational Stage Piagetââ¬â¢s third stage of development is the concrete operational stage. Theà concrete operational stage of development occurs in children between the ages of seven and twelve. Before the beginning of this stage, childrenââ¬â¢s ideas about different objects are formed and dominated by their appearance. An example of this is that they believe there are less toys when they are all piled up rather than spread out across the floor because it takes up more space on the ground. During this stage, the thought process becomes more rational, mature, adult-like, and operational. Children in this stage of development lose their egocentric frame of thought and begin to think logically. This especially is true for the childââ¬â¢s ability to develop logical thought about an object that they are able to physically manipulate. These children have difficulty understanding abstract, hypothetical questions. Children at the concrete-operational level would be expected to draw on the experie nces of others in evaluating their environment, giving more realistic and natural. (Koocher, 1973, p. 2). Formal Operations Stage Piagetââ¬â¢s last stage of development is the formal operational stage. The formal operational stage of development begins at the age of around eleven or twelve and is fully achieved by the age of fifteen and taken throughout the rest of adulthood. The structures of development become the more abstract, logically organized system of adult intelligence. There are two major characteristics of formal operational thought including ââ¬Ëhypothetic-deductive reasoningââ¬â¢ and ââ¬Ëpropositional reasoningââ¬â¢. Hypothetic-deductive reasoning means that when faced with a problem, the person is able to come up with a general summary of all the possible factors that might affect the outcome, and the different outcomes possible. Propositional reasoning means that adolescents can focus on verbal assertions and evaluate their logical validity without making reference to real-world circumstances. In concrete operational development, children can only evaluate the logic of statements based off of concrete evidence. Formal operational development brings critical, theoretical, and problem-solving types of thought that gives them much more thought and understanding than they had in the past. (Koocher, 1973, p. 8). ââ¬Å"Are we forming children who are only capable of learning what is already known? Or should we try to develop creative and innovative minds, capable ofà discovery from the preschool age on, throughout life?â⬠ââ¬âJean Piaget On August 9, 1896, developmental psychologist and philosopher Jean Piaget was born. Jean was the first psychologist to make a systematic study of cognitive development. His contributions include a theory of cognitive child development, detailed observational studies of cognition in children, and a series of simple but ingenious tests to reveal different cognitive abilities. Before Piagetââ¬â¢s work, the common assumption in psychology was that children are merely less competent thinkers than adults which he disproved showing the strikingly different ways children think in comparison to adults. Piagetââ¬â¢s theories of child development continue to be studied in the field of education. His theory differs from others in several ways. For one, it is concerned with children, rather than all learners. It also focuses on development rather than learning so it does not address learning of information or specific behaviors. It proposes discrete stages of development marked by qualitative differences, rather than a gradual increase in number and complexity of behaviors, concepts, and ideas.
Friday, November 15, 2019
Phases Of A Cell Cycle Biology Essay
Phases Of A Cell Cycle Biology Essay Interphase is a part of the cell cycle in which the cell reproduces more DNA, it is the time when a cell accomplishes the most this is the time that the cell is preparing to divide. It is duplicating its organells and increasing the amount of cytoplasm it has in order to undergo cell division interphase constitutes the longest period of the cell cycle and is divided into three successive phases. G1 phase S phase G2 phase 2.1.1. G1 Phase: The first part of the inter phase is G1. In G1phase the cellular metabolic rate is high in which cell normally grows in size. And synthesis of m-RNA, t-RNA, r-RNA and proteins occur. This phase involves accumulation and synthesis of specific enzymes needed to control DNA-synthesis and production of DNA base unit so that the supply is at hand when synthesis being. 2.1.2. S Phase: The S phase is the intermediate phase between G1growth phase (gap-1) and G2 growth phase (gap-2).During the portion of cell cycle the DNA molecule are actually duplicated to produce two similar daughter cells. 2.1.3. G2 Phase: During the gap between DNA synthesis and mitosis, the cell will continue to grow. It is also called pre-mitotic phase. In this phase energy is stored for chromosome movement. Mitotic specific protein RNA and microtubule subunit are synthesis. 2.2. Mitotic Phase: This phase involves the division of nucleus and division of cytoplasm. At this stage the growth and protein production stop. All of the cell cycle focused on the complex and orderly division into two similar daughter cells. Mitosis is much shorter than inter phase. Lasting phase only one two hours. As in both G1 and G2, there is a checkpoint in the middle of mitosis that ensures the cell is ready to complete cell division actually stages of mitosis can be viewed at animal cell mitosis. 3. Mitosis: It is a process of nuclear and cell division in which the numbers of chromosomes in daughter cells are same as that of parent cell. 4. Phases of Mitosis: Mitosis is a continuous process which has two phases. Karyokinesis Cytokinesis 4.1. Karyokinesis: This phase involves the nuclear division .Animal cell has a special structure for cell division called centriole. At the start of mitosis centriole is divided into two pairs. Each pairs migrate to the opposite side of the nucleus thus forming two poles of the dividing cell. The microtubules including aster and spindle are called mitotic apparatus. There size is larger than nucleus. The function of the mitotic apparatus is to attach and capture chromosomes, align them correctly and separate them so that equal distribution of chromosomes should take place. The microtubules are set of fibers which are three in number. They originate from each pair of centrioles. One set of microtubules is called astral microtubules which form aster outward. The other two sets form the spindle in which one is kinetochore microtubules and other is polar microtubules and other is polar microtubules. 4.1.1. Stages of Karyokinesis: Karyokinesis can be divided into four stages. Prophase Metaphase Anaphase Telophase 4.1.1.1. Prophase: Chromosomes can not be seen in the interphase stage even by electron microscope. However by using some special stains chromatin network of fine threads can be seen which is called chromatin. The following events take place in prophase. Nuclear envelope along with nucleoli disappear Centrioles completely migrate towards their poles Mitotic apparatus is organized Cytoplasm becomes more viscous The chromatin material get condensed by folding and chromosomes appear as thin threads and eventually become thick consisting of two chromatids attached with centromere 4.1.1.2. Metaphase: At metaphase chromosomes have become completely thick consisting of chromatid. These chromatids are attached to centromere. The Cells has special area the kinetochore where kinetochore fibres of mitotic apparatus attach. The kinetochore fibers of spindle are attached to kinetochore region of chromosomes and align them at the equator of the spindle forming equatorial plate or metaphase plate. Each kinetochore gets two fibers each from opposite poles. 4.1.1.3. Anaphase: It is very important phase of mitosis. The kinetochore fibers of spindle contract toward their respective poles exert force which separates the two chromatids from centromere. In this way two sister chromatids are formed. Half of them move to one pole and other half towards other pole. 4.1.1.4. Telophase: As the chromosomes reach to their respective pole telophase starts. The chromosome starts unfolding and become chromatin material. Mitotic apparatus starts disappearing while nucleus and nuceolic appears and thus two nucleoli are formed at each pole of the cell. 4.2. Cytokinesis: Cytokinesis is a phase of the mitosis in which whole of the cell divides. At this phase the astral microtubules send signals to equatorial region of cell which activate action and myosin to form contractile ring. This contractile rings form cleavage furrow in the center of cells which get deepens gradually and ultimately divide the parent cell into two daughter cells. 5. MEIOSIS: Meiosis is a special type of cell division in which the numbers of chromosomes in daughter cells are reduced to half as compare to parent cell. In animals it occurs in diploid cells at gamete formation while in plants it takes place at spore formation at gamete formation. Meiosis can take place in two divisions Meiosis I Meiosis II The first meiotic division is reduction division and second meiotic division is like that of mitosis. After two divisions diploid cell produce four haploid cells. 5.1. Stages of Meiosis I: Meiosis I is further divided into four sub-stages as following Prophase I Metaphase I Anaphase Telophase 5.1.1. Prophase I: Prophase I is a very long phase. The chromosomes in this phase behave like the homologous pairs which is different as that from mitosis. The similar chromosomes are called homologous chromosomes. Prophase I is divided into five sub stages. Leptotene Zygotene Pachytene Diplotene Diakinesis 5.1.1.1. Leptotene: At this stage the chromosomes appear as very long narrow thread and the size of nucleus increase and homologous chromosomes become closer. 5.1.1.2. Zygotene: First essential phenomenon of meiosis i.e. pairing of homologous chromosomes called synapsis starts. This pairing is highly specific and exactly pointed, but with no definite starting point. At this phase nuclei also disappears. Each paired but no fused complex structure is called bivalent or tetrad. 5.1.1.3. Pachytene: The pairing of homologous chromosomes is completed. Chromosomes become more and more thick. Each bivalent has four chromatids, which wrap around each other. Non-sister chromatids of homologous chromosomes exchange their segments due to chiasmata formation. During the process called crossing over. In this way reshuffling of genetic materials occur, which produces recombination. 5.1.1.4. Diplotene: The next stage of meiosis is diplotene where bivalents are distinct and contracted. During this phase the chiasmata of each bivalent undergoes terminalization that are the movement of two homologous chromosomes to the two ends. During the stage of prophase due to chromosome contraction they are very distinct as visible bivalent structure. 5.1.1.5. Diakinesis: Next phase is diakinesis where the chiasmata are fully terminalized and the two chromosomes remain together though fully terminalized. 5.1.2. Metaphase I: Nuclear membrane disorganize at the beginning of this phase. Spindle fibres originate and the kinetochore fibres attach to the kinetochore of the homologous chromosomes from each pole and arrange bivalent at the equator. The sister chromatids of individual chromosomes in bivalent behave as a unit. 5.1.3. Anaphase I: In this succeeding anaphase that is Anaphase I, the homologous centromeres move towards opposite direction of the pole. The centromere of each chromosome remains intact. The chromosome being separated there is no chaismata at this stage. 5.1.4. Telophase: Nuclear membranes organize around each set of chromosomes at two poles. Nucleoli reappear thus two nuclei each with half number of chromosome is formed, later on, cytoplasm divides thus terminating the first meiotic division. 6. Summary: Each cell cycle has two phase- interphase and mitotic phase. Inter phase is highly metabolic phase and subdivided into G1, S, G2 phases. Dividing phase involves the division of nucleus and division of cytoplasm. Mitosis is an equational cell division occurs in somatic cells producing two cells of the same chromosomes number of parent cell. Karyokinesis occurs in four phase à ¢Ã ¢Ã¢â¬Å¡Ã ¬prophase, anaphase, metaphase, telophase and is followed by cytokinesis. Meiosis is a reductional cell division occurs in germ cells producing four cells of half chromosomes number from that of parent cell, Nucleus divides twice in meiosis. Prophase I is of longer duration with substages leptotene, zygotene, pachytene. diplotene, diakinesis and is characterized by bivalent formation and crossing over through chaismata formation.
Tuesday, November 12, 2019
Personal Statement for School of Allied Medical Professions
For as long as I can remember, I have been interested in working as a healthcare professional.à Like most children, I was at first interested in the glamour of being a doctor, maybe a surgeon, and saving a personââ¬â¢s life each and every time I workedââ¬âjust like every doctor on every television program for the last two generations, I would be both loved and respected by the people I treated.Over time, of course, a more realistic perspective came into being.à I learned that there were choices other than being the beloved and good-natured general practitioner and the witty and fascinating surgeon.This awareness has sharpened my interest in being a member of the healthcare profession, however, now that I am aware of just how many people contribute in so many different capacities.à Having learned more about the field of respiratory therapy, I am convinced that it is an area in which I can truly make a difference.Unlike many other areas in the healthcare professions, an individual with a baccalaureate degree in respiratory therapy can actually help people change their lives.At that level of study, a person can work either in clinical or non-clinical fields, opening a wide realm of possibilities for future careers from patient care to research to education.à Respiratory therapy requires its practitioners to be both skilled and educated, not only in the very basics of anatomy and physiology, but also in the use of a variety of physical skills and the knowledge to use wide range of sometimes complex equipment.I foresee this degree as one that will launch me on a long-term career in which being a therapist is only the beginning.à I know that I will be able to not only enjoy my work in this field; however, I also know that it will give me the opportunity to build on what I have learned and broaden the reach that I have to be of use to those in need.With a degree from OSU and the entry level licensure that such a degree will allow me to obtain, I know that I would possess the tools that would enable me to be in charge of my own professional destiny.This ability to grow and either diversify or specialize is of great importance to me.à I know that, as a student, it is impossible for me to learn all that I either need to or wish to learn at this level of education.à I have a curious nature and a drive to succeed, both of which should be of benefit in pursuing this lifelong dream of working in healthcare.I also feel that my desire to continue my studies in the future can only help me succeed in a rapidly progressing and changing field.à Continuing education units are not only required by many places of employment to maintain an individualââ¬â¢s position; in my opinion they are also a necessity to keep up with the improvements in techniques and technology if one is truly interested in continuing to serve oneââ¬â¢s patients in the best manner possible.I believe that the program at Ohio State University will give me the background that I require to make an excellent start in my field of choice.à I feel that its limited intake of students would enable me to get the guidance that I would need to excel in the field of my choice when I enter the workforce.I also feel that I can benefit greatly from the wide variety of clinical experiences offered at OSU as I explore what area of respiratory therapy in which I can best offer my skills and knowledge.à Finally, I am excited by the opportunities for research and the possibility to sit for an entry-level licensure exam in my senior year.I realize that both of these opportunities will help me hit the ground running after graduation and help propel me forward as I pursue my future in respiratory therapy.At this point in my educational career, I have taken all of my general education requirements, including courses in biology, chemistry, calculus, physics, medical terminology, and others.à In this upcoming term I will be taking anatomy and physiol ogy.à I feel that my record as a student speaks for itself.From this point forward I realize that I must put all of my efforts into my education.à Studies in my major concentration will allow for few mistakes if I am to succeed in the future and will offer even fewer chances to correct mistakes if they are made.à With so few opportunities to enter the program I know it falls upon me not to waste the chance to finish this degree, if I am permitted the chance to begin.à I am sure that I have the drive to achieve the goals that I have set for myself, as long as I am given the guidance and the knowledge that I need to further myself in my studies.à I am confident that the program at OSU will help me further myself as a student and as a professional in the years to come and would value the chance to learn from such a skilled professional team.Previous to this term, I have taken the opportunity to volunteer at the Grant Medical Center, where I worked in the radiation oncolo gy department.à Although it was not a volunteer opportunity in respiratory therapy, the 50 hours of clinical observation that I did in that area allowed me to see the treatments for bladder cancer, uterine cancer, lung cancer, breast cancer, and brain tumors.The experience both intrigued me and reinforced in me the desire to enter the healthcare field.à The patientsââ¬â¢ will to survive and to thrive was astounding; the dedication that the people at Grant have to help them to survive and to thrive was inspiring.To be honest, such dedication was also a bit frightening, as it occurred to me that there was a great deal of work and personal investment that accompanied it.à While daunting, I know that I am equal to the task ahead, both as a student and as a future professional.I am confident that I have a lot to offer the healthcare profession and even more to offer the field of respiratory therapy.à I know that with my drive and my dedication to my studies that I can achi eve my dreams of working in the healthcare field and can also be an asset to the class with which I study.à I look forward to studying with your fine program in the future.
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